in multiple countries worldwide, which could simplify vaccination schedules and increase adherence.

“We are seeing an unprecedented surge in dengue, with over 14 million cases reported across more than 100 countries in 2024 alone, largely driven by the impacts of climate change and inadequate urbanization. Brazil, consistently among the countries most impacted by dengue, has contributed to the record-breaking number of dengue cases and rise in severity and deaths. This surge highlights the urgent need for prevention methods like QDENGA,” said Edson Moreira, M.D., Senior Researcher at Oswaldo Cruz Foundation, Brazilian Ministry of Health. “The inclusion of QDENGA in Brazil's public vaccination program has reduced symptomatic dengue cases and dengue-related hospitalizations.”

After 4.5 years, two doses of QDENGA provided 61.2% [95% CI: 56.0, 65.8] vaccine efficacy (VE) in preventing virologically confirmed dengue (VCD).1A booster dose admin
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