f both primary IgA nephropathy (NCT06963827) and chronic immune thrombocytopenia (NCT06722235) with the first patients now enrolled. In October 2025, mezagitamab was granted Orphan Drug Designation by the European Medicines Agency for the treatment of primary IgA nephropathy. In August 2025, mezagitamab was granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration for the treatment of adult patients with chronic immune thrombocytopenia who have had an insufficient response to previous treatment. Takeda is assessing additional indications for mezagitamab.

About Mezagitamab

Mezagitamab is a fully human, anti-CD38 IgG1 monoclonal antibody that depletes cells that are high expressors of CD-38, such as plasma cells, plasmablasts and natural killer cells. Depletion of these cells is predicted to decrease formation of immune complexes, reduce inflammation and thus the resulting proteinuria, ultimately preventing further injury to the kidneys and pro
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