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TakedaPresentsNewDataShowingMezagitamab(TAK-079)SustainedEffectonKidneyFunction18MonthsAfterTreatmentinPrimaryIgANephropathy
===2025/11/10 15:13:58===
p with a 48-week observation period. The primary endpoint was the percentage of participants with adverse events (AEs), including grade ≥3 AEs and serious AEs, up to Week 96.1Secondary and exploratory endpoints included serum IgA, IgG and Gd-IgA1 levels, percentage change from baseline in UPCR, change from baseline in eGFR and resolution of hematuria (blood in urine).1

About Immunoglobulin A Nephropathy

Immunoglobulin A (IgA) nephropathy is a lifelong progressive autoimmune disease often diagnosed in young people aged 10-30 years old that causes irreversible damage to the kidney function.2It is caused by deposits of immune complexes inside the filters in the kidney, which trigger inflammation and damage to the kidney tissue, resulting in loss of renal function.2

There is no cure for IgA nephropathy.3It is associated with a poor prognosis and can progress to kidney failure, which can lead to reduced quality of life or premature death.1Approximately one i
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