, active-controlled phase III studies investigating the products in 171 and 162 subjects, respectively. Restylane Refyne and Defyne met the studies’ endpoints, demonstrating a clinically meaningful improvement in wrinkle severity for up to 12 months, with most patients reporting at least a 1-grade improvement in self-assessment scores after six weeks.1,2








“The approval of Restylane Defyne and Refyne – the first OBT HA injectables ever authorized in Japan – is a landmark moment for Galderma in the region. A decade after NASHA’s introduction to this market, we are proud to now offer a fully rounded Restylane portfolio that gives healthcare professionals even more precision and flexibility to meet the needs of their patients. Japan is an important growth engine for our business, and this milestone underscores our long-term commitment to bringing world-leading aesthetic technologies to
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